Asymmetric chiral ligand-directed alkene dioxygenation.

ABSTRACT: A Pd-catalyzed asymmetric alkene 1,2-dioxygenation reaction is described. The diastereoselectivity of the reaction is controlled by tethering a chiral oxime ether directing group to the alkene substrate. The best selectivities are obtained with 8-substituted menthone-derived oxime ether auxiliaries.

SUBMITTER: Neufeldt SR 

PROVIDER: S-EPMC3600423 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature