Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genes.

ABSTRACT:

Background

Methylation of deoxyribonucleic acid (DNA) is an epigenetic regulator of gene expression that changes with age, but its contribution to aging-related disorders, including high blood pressure (BP), is still largely unknown. We examined the relation of BP to the methylation of retrotransposon sequences of DNA and of selected candidate genes.

Methods

This investigation included 789 elderly participants in the Normative Aging Study, ranging in age from 55 to 100 years, who had longitudinal measurements of DNA methylation. In these subjects' DNA we measured the proportion of methylated sites in retrotransposable sequences and in pro-inflammatory genes, expressed as the percent of 5-methylated cytosines (%5mC) among all cytosines. From one to four methylation measuremen

SUBMITTER: Alexeeff SE 

PROVIDER: S-EPMC3600626 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature