An f2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans: design and genetic parameters.

ABSTRACT: Obesity is a rising worldwide public health problem. Difficulties to precisely measure various obesity traits and the genetic heterogeneity in human have been major impediments to completely disentangle genetic factors causing obesity. The pig is a relevant model for studying human obesity and obesity-related (OOR) traits. Using founder breeds divergent with respect to obesity traits we have created an F2 pig resource population (454 pigs), which has been intensively phenotyped for 36 OOR traits. The main rationale for our study is to characterize the genetic architecture of OOR traits in the F2 pig design, by estimating heritabilities, genetic, and phenotypic correlations using mixed- and multi-trait BLUP animal models. Our analyses revealed high coefficients of variation (15-42%) and mod

SUBMITTER: Kogelman LJ 

PROVIDER: S-EPMC3600696 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature