Evaluation of GWAS-identified genetic variants for age at menarche among Chinese women.

ABSTRACT:

Study question

Do genetic polymorphisms which influence age at menarche in women of European ancestry also influence women of Chinese ancestry?

Summary answer

Many genetic variants influencing age at menarche in European populations appear to impact Chinese populations in a similar manner.

What is known and what this paper adds

Prior genome-wide association studies have uncovered 42 SNPs associated with age at menarche in European populations. This study is the first to demonstrate that many of the genetic determinants of age at menarche are shared between European and Chinese women.

Participants and setting

We evaluated 37 of 42 SNPs identified as associated with age at menarche from a recent, large meta-analysis, consisting primarily of women of European ance

SUBMITTER: Delahanty RJ 

PROVIDER: S-EPMC3600840 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature