Inflammation biomarkers in vaginal fluid and preterm delivery.

ABSTRACT:

Study question

Which inflammation biomarkers detected in the vaginal fluid are most informative for identifying preterm delivery (PTD) risk?

Summary answer

Elevated interleukin (IL)-6 at mid-trimester was associated with increased odds of spontaneous PTD at <35 weeks and with PTD plus histologic chorioamnionitis (HCA), and had the greatest sensitivity for detecting these two PTD subtypes.

What is known already

Maternal and/or fetal inflammation play a role in some preterm deliveries, therefore inflammation biomarkers might help to identify women at greater risk.

Study design, size, duration

We examined 1115 women from the Pregnancy Outcomes and Community Health Study, a cohort study conducted from September 1998 through June 2004, for whom data were available o

SUBMITTER: Taylor BD 

PROVIDER: S-EPMC3600841 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature