Global gene expression profiling reveals SPINK1 as a potential hepatocellular carcinoma marker.

ABSTRACT:

Background

Liver cirrhosis is the most important risk factor for hepatocellular carcinoma (HCC) but the role of liver disease aetiology in cancer development remains under-explored. We investigated global gene expression profiles from HCC arising in different liver diseases to test whether HCC development is driven by expression of common or different genes, which could provide new diagnostic markers or therapeutic targets.

Methodology and principal findings

Global gene expression profiling was performed for 4 normal (control) livers as well as 8 background liver and 7 HCC from 3 patients with hereditary haemochromatosis (HH) undergoing surgery. In order to investigate different disease phenotypes causing HCC, the data were compared with public microarray repositories for ge

SUBMITTER: Marshall A 

PROVIDER: S-EPMC3601070 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature