Phase I clinical trial combining imatinib mesylate and IL-2: HLA-DR⁺ NK cell levels correlate with disease outcome.

ABSTRACT: We performed a Phase I clinical trial from October 2007 to October 2009, enrolling patients affected by refractory solid tumors, to determine the maximum tolerated dose (MTD) of interleukin (IL)-2 combined with low dose cyclophosphamide (CTX) and imatinib mesylate (IM). In a companion paper published in this issue of OncoImmunology, we show that the MTD of IL-2 is 6 MIU/day for 5 consecutive days, and that IL-2 increases the impregnation of both IM and of its main metabolite, CGP74588. Among the secondary objectives, we wanted to determine immunological markers that might be associated with progression-free survival (PFS) and/or overall survival (OS). The combination therapy markedly reduced the absolute counts of B, CD4⁺ T and CD8⁺ T cells in a manner that was

SUBMITTER: Chaput N 

PROVIDER: S-EPMC3601178 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature