Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila.

ABSTRACT: Complex organ shapes arise from the coordinate actions of individual cells. The Drosophila egg chamber is an organ-like structure that lengthens along its anterior-posterior axis as it grows. This morphogenesis depends on an unusual form of planar polarity in the organ's outer epithelial layer, the follicle cells. Interestingly, this epithelium also undergoes a directed migration that causes the egg chamber to rotate around its anterior-posterior axis. However, the functional relationship between planar polarity and migration in this tissue is unknown. We have previously reported that mutations in the Misshapen kinase disrupt follicle cell planar polarity. Here we show that Misshapen's primary role in this system is to promote individual cell motility. Misshapen decreases integrin levels a

SUBMITTER: Lewellyn L 

PROVIDER: S-EPMC3601364 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature