Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD.

ABSTRACT:

Objective

A major motivation for seeking disease-associated genetic variation is to identify novel risk processes. Although rare copy number variants (CNVs) appear to contribute to attention deficit hyperactivity disorder (ADHD), common risk variants (single-nucleotide polymorphisms [SNPs]) have not yet been detected using genome-wide association studies (GWAS). This raises the concern as to whether future larger-scale, adequately powered GWAS will be worthwhile. The authors undertook a GWAS of ADHD and examined whether associated SNPs, including those below conventional levels of significance, influenced the same biological pathways affected by CNVs.

Method

The authors analyzed genome-wide SNP frequencies in 727 children with ADHD and 5,081 comparison subjects. The gene set

SUBMITTER: Stergiakouli E 

PROVIDER: S-EPMC3601404 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature