Functional connectivity of left Heschl's gyrus in vulnerability to auditory hallucinations in schizophrenia.

ABSTRACT:

Background

Schizophrenia is a heterogeneous disorder that may consist of multiple etiologies and disease processes. Auditory hallucinations (AH), which are common and often disabling, represent a narrower and more basic dimension of psychosis than schizophrenia. Previous studies suggest that abnormal primary auditory cortex activity is associated with AH pathogenesis. We thus investigated functional connectivity, using a seed in primary auditory cortex, in schizophrenia patients with and without AH and healthy controls, to examine neural circuit abnormalities associated more specifically with AH than the myriad other symptoms that comprise schizophrenia.

Methods

Using resting-state fMRI (rsfMRI), we investigated functional connectivity of the primary auditory cortex, located

SUBMITTER: Shinn AK 

PROVIDER: S-EPMC3601525 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature