Ictal adiponectin levels in episodic migraineurs: a randomized pilot trial.

ABSTRACT:

Objective

To assess ictal adiponectin (ADP) levels before and after acute abortive treatment in women episodic migraineurs.

Methods

Peripheral blood specimens were collected from women episodic migraineurs before and after acute abortive treatment with sumatriptan/naproxen sodium vs placebo. Univariate and multivariate models were utilized to examine the relationship between serum total ADP (T-ADP), ADP oligomers (high molecular weight [HMW], middle molecular weight, and low molecular weight [LMW]-ADP), and ADP ratio levels and pain severity. Paired t-tests and random intercept longitudinal models were utilized to assess the mean changes in T-ADP, ADP oligomers, and ratios over time in treatment responders and nonresponders.

Results

Twenty participants (11 responders,

SUBMITTER: Peterlin BL 

PROVIDER: S-EPMC3601586 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature