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Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA.

ABSTRACT: We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46?656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC3601739 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA.

Zhang Wenyu W   Bryson David I DI   Crumpton Jason B JB   Wynn Jessica J   Santos Webster L WL  

Chemical communications (Cambridge, England) 20130301 24

We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA. ...[more]

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