Tissue-selective regulation of androgen-responsive genes.

ABSTRACT:

Introduction

Androgens regulate a wide array of physiological processes, including male sexual development, bone and muscle growth, and behavior and cognition. Because androgens play a vital role in so many tissues, changes in androgen signaling are associated with a plethora of diseases. How such varied responses are achieved by a single stimulus is not well understood. Androgens act primarily through the androgen receptor (AR), a hormone nuclear receptor that is expressed in a select variety of tissues.

Methods

In order to gain a better understanding of how the tissue-selective effects of androgens are achieved, we performed a comparison of microarray data, using previously published datasets and several of our own microarray datasets. These datasets were derived from clin

SUBMITTER: Otto-Duessel M 

PROVIDER: S-EPMC3601834 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature