Energy balance, polymorphisms in the mTOR pathway, and renal cell carcinoma risk.

ABSTRACT:

Background

The interplay between obesity, physical activity, weight gain, and genetic variants in the mTOR pathway has not been studied in renal cell carcinoma (RCC). We examined the associations between obesity, weight gain, physical activity, and RCC risk. We also analyzed whether genetic variants in the mTOR pathway could modify the association.

Methods

Incident RCC case subjects and healthy control subjects were recruited from the University of Texas MD Anderson Cancer Center in Houston, Texas. Case subjects and control subjects were frequency matched. Epidemiologic data were collected by in-person interview. One hundred ninety single nucleotide polymorphisms (SNPs) from 22 genes in the mTOR pathway were extracted from previous genome-wide association studies. Logistic r

SUBMITTER: Shu X 

PROVIDER: S-EPMC3601952 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature