Responsiveness of the MOS-HIV and EQ-5D in HIV-infected adults receiving antiretroviral therapies.

ABSTRACT:

Background

Selection of an appropriate patient-reported outcome (PRO) instrument for a clinical trial requires knowledge of the instrument's responsiveness to detecting treatment effects. The purpose of this study was to examine the responsiveness of two health-related quality of life (HRQL) instruments used in clinical trials involving HIV-infected adults: the HIV-targeted Medical Outcomes Study HIV Health Survey (MOS-HIV), and a generic measure, the EuroQol-5D (EQ-5D).

Methods

A systematic review identified clinical trials using the MOS-HIV or EQ-5D to assess outcomes for HIV-infected adults. Data abstracted from each study included study type, treatment regimen(s), PRO results, and effect size (either reported or calculated). Effect size was calculated as the difference b

SUBMITTER: Wu AW 

PROVIDER: S-EPMC3602001 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature