Rab25 regulates invasion and metastasis in head and neck cancer.

ABSTRACT:

Purpose

Head and neck squamous cell carcinoma (HNSCC) is one of the 10 most common cancers with a 50% five-year survival rate, which has remained unchanged for the past three decades. One of the major reasons for the aggressiveness of this cancer is that HNSCCs readily metastasize to cervical lymph nodes that are abundant in the head and neck region. Hence, discovering new molecules controlling the metastatic process as well as understanding their regulation at the molecular level are essential for effective therapeutic strategies.

Experimental design

Rab25 expression level was analyzed in HNSCC tissue microarray. We used a combination of intravital microscopy in live animals and immunofluorescence in an in vitro invasion assay to study the role of Rab25 in tumor cell migrat

SUBMITTER: Amornphimoltham P 

PROVIDER: S-EPMC3602237 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature