Sex-influenced association of nonalcoholic fatty liver disease with coronary heart disease.

ABSTRACT:

Objective

This study investigated whether nonalcoholic fatty liver disease (NAFLD) predicts prevalent coronary heart disease (CHD).

Methods

Epidemiologic studies have used various definitions for NAFLD. Here, we considered both liver fat burden measured by CT (FL) and the non-specific measure of hepatic inflammation -alanine aminotransferase (ALT). The association of FL and ALT with CHD (self report of coronary bypass, myocardial infarction, or percutaneous transluminal coronary angioplasty) was investigated in 2756 European-American participants of the Family Heart Study.

Results

FL (p = 0.0084) and ALT (≥40 U/L, p = 0.014) were each individually associated with prevalent CHD. However, when accounting for traditional metabolic risk factors in a multivariate model FL

SUBMITTER: Feitosa MF 

PROVIDER: S-EPMC3602396 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature