A single nucleotide polymorphism in inflammatory gene RNASEL predicts outcome after radiation therapy for localized prostate cancer.

ABSTRACT:

Purpose

To study associations between single nucleotide polymorphisms (SNP) in Ribonuclease L (RNASEL), a gene implicated in inflammation and prostate cancer risk, and outcomes after radiation therapy.

Experimental design

We followed participants in the prospective US Health Professionals Follow-Up Study treated with radiation therapy for early-stage prostate cancer. Three SNPs were genotyped based on previously determined functional and biological significance. We used multivariable Cox proportional hazards models to assess per-allele associations with the primary outcome defined as time to a composite endpoint including development of lethal prostate cancer or biochemical recurrence.

Results

We followed 434 patients treated with radiation therapy for a median of 9 y

SUBMITTER: Schoenfeld JD 

PROVIDER: S-EPMC3602407 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature