Predicted binding of certain antifilarial compounds with glutathione-S-transferase of human Filariids.

ABSTRACT:

Unlabelled

: Glutathione-S-transferase is a major phase-II detoxification enzyme in parasitic helminthes. Previous research highlights the importance of GSTs in the establishment of chronic infections in cytotoxic microenvironments. Filarial nematodes depend on these detoxification enzymes for their survival in the host. GST plays an important role in filariasis and other diseases. GST from W.bancrofti and B.malayi are very much different from human GST. This structural difference makes GST potential chemotherapeutic targets for antifilarial treatment. In this study we have checked the efficacy of some well known antifilarial compounds against GST from B.malayi and W.bancrofti. The structure of BmGST was modeled using modeller9v10 and was submitted to PMDB. Molecular docking study

SUBMITTER: Saeed M 

PROVIDER: S-EPMC3602877 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature