How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD.

ABSTRACT: Exposure to traumatic events that produce extreme fear and horror is all too common in both military and civilian populations, but not all individuals develop posttraumatic stress disorder (PTSD) as a result of the exposure. What mediates risk and resilience in the development of PTSD and other stress-related psychopathology is of paramount importance to our further understanding of trauma-related psychopathology as well as the development of new treatment approaches. Biological factors, such as genotype and neurobiology, interact with environmental factors, such as childhood background and trauma load, to affect vulnerability and resilience in the aftermath of trauma exposure. One of the core symptoms of PTSD is the inability to control fear, which has led some investigators and clinician

SUBMITTER: Jovanovic T 

PROVIDER: S-EPMC3603297 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature