Codon usage bias and effective population sizes on the X chromosome versus the autosomes in Drosophila melanogaster.

ABSTRACT: Codon usage bias (CUB) in Drosophila is higher for X-linked genes than for autosomal genes. One possible explanation is that the higher effective recombination rate for genes on the X chromosome compared with the autosomes reduces their susceptibility to Hill-Robertson effects, and thus enhances the efficacy of selection on codon usage. The genome sequence of D. melanogaster was used to test this hypothesis. Contrary to expectation, it was found that, after correcting for the effective recombination rate, CUB remained higher on the X than on the autosomes. In contrast, an analysis of polymorphism data from a Rwandan population showed that mean nucleotide site diversity at 4-fold degenerate sites for genes on the X is approximately three-quarters of the autosomal value after correcting for

SUBMITTER: Campos JL 

PROVIDER: S-EPMC3603305 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature