The evolutionary dynamics of protein-protein interaction networks inferred from the reconstruction of ancient networks.

ABSTRACT: Cellular functions are based on the complex interplay of proteins, therefore the structure and dynamics of these protein-protein interaction (PPI) networks are the key to the functional understanding of cells. In the last years, large-scale PPI networks of several model organisms were investigated. A number of theoretical models have been developed to explain both the network formation and the current structure. Favored are models based on duplication and divergence of genes, as they most closely represent the biological foundation of network evolution. However, studies are often based on simulated instead of empirical data or they cover only single organisms. Methodological improvements now allow the analysis of PPI networks of multiple organisms simultaneously as well as the direct model

SUBMITTER: Jin Y 

PROVIDER: S-EPMC3603955 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature