Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells.

ABSTRACT: Matrix metalloproteinase-7 (MMP7) expression is quickly up-regulated after injury, and functions to regulate wound repair and various mucosal immune processes. We evaluated the global transcriptional response of airway epithelial cells from wild-type and Mmp7-null mice cultured at an air-liquid interface. The analysis of differentially expressed genes between genotypes after injury revealed an enrichment of functional categories associated with inflammation, cilia, and differentiation. Because these analyses suggested that MMP7 regulated ciliated cell formation, we evaluated the recovery of the airway epithelium in wild-type and Mmp7-null mice in vivo after naphthalene injury, which revealed augmented ciliated cell formation in the absence of MMP7. Moreover, in vitro studies evaluating cel

SUBMITTER: Gharib SA 

PROVIDER: S-EPMC3604090 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature