Striatum-dependent habits are insensitive to both increases and decreases in reinforcer value in mice.

ABSTRACT: The mouse has emerged as an advantageous species for studying the brain circuitry that underlies complex behavior and for modeling neuropsychiatric disease. The transition from flexible, goal-directed actions to inflexible, habitual responses is argued to be a valid and reliable behavioral model for studying a core aspect of corticostriatal systems that is implicated in certain forms of psychopathology. This transition is thought to correspond to a progression of behavioral control from associative to sensorimotor corticobasal ganglia networks. Habits form following extensive training and are characterized by reduced sensitivity of instrumental responding to reinforcer revaluation; few studies have examined this form of behavioral control in mice. Here we examined the involvement of the do

SUBMITTER: Quinn JJ 

PROVIDER: S-EPMC3604187 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature