Implementation of standardized assessment and reporting of myocardial infarction in contemporary randomized controlled trials: a systematic review.

ABSTRACT: Myocardial infarction (MI) is a key endpoint in randomized controlled trials (RCTs), but heterogeneous definitions limit comparisons across RCTs or meta-analyses. The 2000 European Society of Cardiology/American College of Cardiology MI redefinition and the 2007 universal MI definition consensus documents made recommendations to address this issue. In cardiovascular randomized trials, we evaluated the impact of implementation of three key recommendations from these reports-troponin use to define MI; separate reporting of spontaneous and procedure-related MI; and infarct size reporting. We searched ClinicalTrials.gov and MEDLINE databases for cardiovascular RCTs with more than 500 patients in which enrolment began between September 2000 and July 2012 and that listed MI in the primary endpoi

SUBMITTER: Leonardi S 

PROVIDER: S-EPMC3604645 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature