Evolutionary analysis points to divergent physiological roles of type 1 fimbriae in Salmonella and Escherichia coli.

ABSTRACT:

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Salmonella and Escherichia coli mannose-binding type 1 fimbriae exhibit highly similar receptor specificities, morphologies, and mechanisms of assembly but are nonorthologous in nature, i.e., not closely related evolutionarily. Their operons differ in chromosomal location, gene arrangement, and regulatory components. In the current study, we performed a comparative genetic and structural analysis of the major structural subunit, FimA, from Salmonella and E. coli and found that FimA pilins undergo diverse evolutionary adaptation in the different species. Whereas the E. coli fimA locus is characterized by high allelic diversity, frequent intragenic recombination, and horizontal movement, Salmonella fimA shows structural diversity that is more than 5-fold lower without stro

SUBMITTER: Kisiela DI 

PROVIDER: S-EPMC3604780 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature