Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population.

ABSTRACT:

Background

Angiotensinogen (AGT) constitutes a central component of the renin-angiotensin system that controls the systemic blood pressure and several other cardiovascular functions and may play an important role in atherosclerosis pathways. In this study, we employed TaqMan genotyping assays to evaluate the role of 8 AGT variants in primary hypertension (HTN), type 2 diabetes mellitus (T2DM), and obesity as a possible trigger of coronary artery disease (CAD) in a population of 4615 angiographed native Saudi individuals.

Methods

Linkage analysis was done by using the Affymetrix Gene Chip array, sequencing by using the MegaBACE DNA analysis system and genotyping accomplished by TaqMan chemistry using the Applied Biosystem real-time Prism 7900HT Sequence Detection System.

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SUBMITTER: Al-Najai M 

PROVIDER: S-EPMC3605175 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature