Physical activity, genes for physical fitness, and risk of coronary heart disease.

ABSTRACT:

Purpose

Both physical activity and physical fitness are associated with decreased coronary heart disease (CHD) risk. Our objective was to determine whether genes associated with physical fitness modify the association between physical activity and CHD.

Methods

We conducted a prospective cohort study among 23,016 initially healthy women in the Women's Genome Health Study. Leisure time physical activity was reported at entry and during follow-up. A total of 58 single nucleotide polymorphisms associated with physical fitness were identified from published literature and summed to create four separate genetic scores related to phenotypes of endurance, muscle strength, V˙O2max, and overall fitness.

Results

During a median of 14.4 yr, 320 incident CHD events occurred. Incre

SUBMITTER: Chomistek AK 

PROVIDER: S-EPMC3605203 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature