AD pathology and cerebral infarctions are associated with memory and executive functioning one and five years before death.
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ABSTRACT:
SUBMITTER: Yang FM
PROVIDER: S-EPMC3605227 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
AD pathology and cerebral infarctions are associated with memory and executive functioning one and five years before death.
Yang Frances M FM Grigorenko Alexander A Tommet Doug D Farias Sarah T ST Mungas Dan D Bennett David A DA Jones Richard N RN Crane Paul K PK
Journal of clinical and experimental neuropsychology 20121203 1
We provide rigorous psychometric evidence for distinct patterns of cognitive impairment for Alzheimer's disease (AD) and cerebral infarctions using 440 participants from the Religious Order Study. Latent variable models were used to decompose the effects of AD pathology and cerebral infarctions assessed at autopsy on overall cognition and specific neuropsychological tests at one and five years prior to death. Results support clinical and univariate psychometric analyses that memory impairment is ...[more]
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