Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria.

ABSTRACT:

Background

The malaria caused by Plasmodium falciparum remains a serious public health problem in the world, due largely to the absence of an effective vaccine. There is a lack of information on the structural properties and antigens capable of activating the immunological mechanisms for the induction of protective immunity. Therefore, the objective of this study is to evaluate the serological reactivity of sera from individuals with imported malaria and identify major immunogenic proteins.

Methods

The study was conducted in 227 individuals with imported malaria and 23 healthy individuals who had never been in areas endemic for malaria. The determination of anti-P. falciparum IgG antibodies was performed by an ELISA validated and optimized for this study. Sera showing higher

SUBMITTER: Costa RM 

PROVIDER: S-EPMC3605388 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature