Discovery analysis of TCGA data reveals association between germline genotype and survival in ovarian cancer patients.

ABSTRACT:

Background

Ovarian cancer remains a significant public health burden, with the highest mortality rate of all the gynecological cancers. This is attributable to the late stage at which the majority of ovarian cancers are diagnosed, coupled with the low and variable response of advanced tumors to standard chemotherapies. To date, clinically useful predictors of treatment response remain lacking. Identifying the genetic determinants of ovarian cancer survival and treatment response is crucial to the development of prognostic biomarkers and personalized therapies that may improve outcomes for the late-stage patients who comprise the majority of cases.

Methods

To identify constitutional genetic variations contributing to ovarian cancer mortality, we systematically investigated as

SUBMITTER: Braun R 

PROVIDER: S-EPMC3605427 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature