MODexplorer: an integrated tool for exploring protein sequence, structure and function relationships.

ABSTRACT:

Summary

MODexplorer is an integrated tool aimed at exploring the sequence, structural and functional diversity in protein families useful in homology modeling and in analyzing protein families in general. It takes as input either the sequence or the structure of a protein and provides alignments with its homologs along with a variety of structural and functional annotations through an interactive interface. The annotations include sequence conservation, similarity scores, ligand-, DNA- and RNA-binding sites, secondary structure, disorder, crystallographic structure resolution and quality scores of models implied by the alignments to the homologs of known structure. MODexplorer can be used to analyze sequence and structural conservation among the structures of similar proteins, to f

SUBMITTER: Kosinski J 

PROVIDER: S-EPMC3605600 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature