New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

ABSTRACT: Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal

SUBMITTER: Horikoshi M 

PROVIDER: S-EPMC3605762 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature