Early gene expression divergence between allopatric populations of the house mouse (Mus musculus domesticus).

ABSTRACT: Divergence of gene expression is known to contribute to the differentiation and separation of populations and species, although the dynamics of this process in early stages of population divergence remains unclear. We analyzed gene expression differences in three organs (brain, liver, and testis) between two natural populations of Mus musculus domesticus that have been separated for at most 3000 years. We used two different microarray platforms to corroborate the results at a large scale and identified hundreds of genes with significant expression differences between the populations. We find that although the three tissues have similar number of differentially expressed genes, brain and liver have more tissue-specific genes than testis. Most genes show changes in a single tissue only, even

SUBMITTER: Bryk J 

PROVIDER: S-EPMC3605846 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature