Genetic predisposition to pass the standard SICCT test for bovine tuberculosis in British cattle.

ABSTRACT: Bovine tuberculosis (bTB) imposes an important financial burden on the British cattle industry, yet despite intense efforts to control its spread, incidence is currently rising. Surveillance for bTB is based on a skin test that measures an immunological response to tuberculin. Cattle that fail the test are classified as "reactors" and slaughtered. Recent studies have identified genetic markers associated with the reaction of cattle to the tuberculin test. At marker INRA111 a relatively common '22' genotype occurs significantly more frequently in non-reactor cattle. Here we test the possibility that the putative protective '22' genotype does not confer resistance but instead causes cattle that carry it to react less strongly to the prescribed test, and hence avoid slaughter, potentially eve

SUBMITTER: Amos W 

PROVIDER: S-EPMC3605902 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature