Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka T
PROVIDER: S-EPMC3605996 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Tanaka Torahiko T Kuroda Kazumichi K Ikeda Masanori M Wakita Takaji T Kato Nobuyuki N Makishima Makoto M
Journal of lipid research 20130112 4
Lipid droplets (LD) are dynamic storage organelles that are involved in lipid homeostasis. Hepatitis C virus (HCV) is closely associated with LDs. HCV Core and nonstructural (NS) proteins colocalize with LDs and presumably are involved in virion formation at that site. We demonstrated that HCV NS4B, an integral membrane protein in endoplasmic reticulum (ER), strongly targeted LDs. Confocal imaging studies showed that NS4B localized at the margins of LDs. Biochemical fractionation of HCV-replicat ...[more]