A genome-wide association study on African-ancestry populations for asthma.

ABSTRACT:

Background

Asthma is a complex disease characterized by striking ethnic disparities not explained entirely by environmental, social, cultural, or economic factors. Of the limited genetic studies performed on populations of African descent, notable differences in susceptibility allele frequencies have been observed.

Objectives

We sought to test the hypothesis that some genes might contribute to the profound disparities in asthma.

Methods

We performed a genome-wide association study in 2 independent populations of African ancestry (935 African American asthmatic cases and control subjects from the Baltimore-Washington, DC, area and 929 African Caribbean asthmatic subjects and their family members from Barbados) to identify single-nucleotide polymorphisms (SNPs) associat

SUBMITTER: Mathias RA 

PROVIDER: S-EPMC3606015 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature