Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era.

ABSTRACT:

Objective

To determine relationship of echocardiographic measures of pulmonary hypertension to lung function and inflammatory biomarkers in HIV-infected individuals.

Design

Cross-sectional study of 116 HIV-infected outpatients.

Methods

Doppler-echocardiography and pulmonary function testing were performed. Induced sputum and plasma cytokines, sputum cell counts and differentials, markers of peripheral T-cell activation, and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured. Univariate and multivariate analyses determined relationship of echocardiographic variables to pulmonary function, inflammation, and NT-proBNP.

Results

Mean estimated pulmonary artery systolic pressure (PASP) was 34.3 mmHg (SD 6.9) and mean tricuspid regurgitant jet ve

SUBMITTER: Morris A 

PROVIDER: S-EPMC3606053 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature