Harmonization and semantic annotation of data dictionaries from the Pharmacogenomics Research Network: a case study.

ABSTRACT: The Pharmacogenomics Research Network (PGRN) is a collaborative partnership of research groups funded by NIH to discover and understand how genome contributes to an individual's response to medication. Since traditional biomedical research studies and clinical trials are often conducted independently, common and standardized representations for data are seldom used. This leads to heterogeneity in data representation, which hinders data reuse, data integration and meta-analyses. This study demonstrates harmonization and semantic annotation work for pharmacogenomics data dictionaries collected from PGRN research groups. A semi-automated system was developed to support the harmonization/annotation process, which includes four individual steps, (1) pre-processing PGRN variables; (2) decomposin

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC3606279 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature