Protein network-based Lasso regression model for the construction of disease-miRNA functional interactions.

ABSTRACT:

Background

There is a growing body of evidence associating microRNAs (miRNAs) with human diseases. MiRNAs are new key players in the disease paradigm demonstrating roles in several human diseases. The functional association between miRNAs and diseases remains largely unclear and far from complete. With the advent of high-throughput functional genomics techniques that infer genes and biological pathways dysregulted in diseases, it is now possible to infer functional association between diseases and biological molecules by integrating disparate biological information.

Results

Here, we first used Lasso regression model to identify miRNAs associated with disease signature as a proof of concept. Then we proposed an integrated approach that uses disease-gene associations from micr

SUBMITTER: Qabaja A 

PROVIDER: S-EPMC3606436 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature