Reference intervals for serum osteocalcin concentrations in adult men and women from the study of health in Pomerania.

ABSTRACT:

Background

Osteocalcin (OC) is a bone-specific protein produced primarily by osteoblasts during bone formation. Besides its role in bone formation, osteocalcin may play a role in the regulation of energy metabolism and male fertility. To interpret serum OC data, reference intervals adapted to a specific laboratory method are needed.

Methods

A healthy reference population was selected from the first follow-up of the Study of Health in Pomerania. Serum OC concentrations were measured with the IDS-iSYS N-Mid Osteocalcin assay on the IDS-iSYS Automated System (Immunodiagnostic Systems, Frankfurt am Main, Germany). The reference interval was defined as the central 95% range (2.5th-97.5th percentile). Age-specific reference intervals were calculated by quantile regression for 1107

SUBMITTER: Hannemann A 

PROVIDER: S-EPMC3606466 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature