A comparison of tests for Hardy-Weinberg Equilibrium in national genetic household surveys.

ABSTRACT:

Background

This study is motivated by National Household Surveys that collect genetic data, in which complex samples (e.g. stratified multistage cluster sample), partially from the same family, are selected. In addition to the differential selection probabilities of selecting households and persons within the sampled households, there are two levels of correlations of the collected genetic data in National Genetic Household Surveys (NGHS). The first level of correlation is induced by the hierarchical geographic clustered sampling of households and the second level of correlation is induced by biological inheritances from individuals sampled in the same household.

Results

To test for Hardy-Weinberg Equilibrium (HWE) in NGHS, two test statistics, the CCS method [1] and the QS

SUBMITTER: Li Y 

PROVIDER: S-EPMC3606615 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature