Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naive patients with adolescent bipolar disorder.

ABSTRACT:

Background

In response to emotional faces, patients with adolescent bipolar disorder (ABD) exhibit increased neural activity in subcortical emotional processing regions (e.g., amygdala, ventral striatum) and variable prefrontal activity. We extend previous research by identifying cortical and subcortical regions showing altered hemodynamic response shapes in ABD relative to healthy controls (HC).

Methods

ABD (N=65) and matched HC (N=79) completed a slow event-related affective hemodynamic probe task that required indicating the gender of fearful and neutral faces. An informed basis set in SPM8 evaluated shape variations of the hemodynamic responses to these faces.

Results

Patients with ABD showed higher activity for fearful relative to neutral faces in the amygdala an

SUBMITTER: Wegbreit E 

PROVIDER: S-EPMC3606663 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature