Genomic determinants of motor and cognitive outcomes in Parkinson's disease.

ABSTRACT:

Background

Little is known regarding genetic factors associated with motor or cognitive outcomes in Parkinson's disease (PD).

Objective

To identify common genetic variants associated with motor and cognitive outcomes in PD.

Methods

The sample consisted of 443 PD cases included in the first genome-wide association study (GWAS) of PD. Methods included telephone interview assessments of motor and cognitive outcomes, a median 9 years following the initial clinical assessments. Analyses included Cox proportional hazard models to study the association of 198,345 single nucleotide polymorphisms (SNPs) with survival free of Hoehn and Yahr stage ≥ 4 (motor outcome), and either TICS-M ≤ 27 or AD-8 ≥ 2 (cognitive outcomes).

Results

The SNP rs10958605 in the C8orf4 gene ha

SUBMITTER: Chung SJ 

PROVIDER: S-EPMC3606821 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature