BF₃·OEt₂-Promoted Concise Synthesis of Difluoroboron-Derivatized Curcumins from Aldehydes and 2,4-Pentanedione.

ABSTRACT: A concise and one-pot cascade method has been developed to achieve the synthesis of difluoroboron-derivatized curcumins (BF₂C). Treatment of 2,4-pentanedione with BF₃·OEt₂, followed by condensation with aldehydes in the presence of tributyl borate and butylamine at 65 °C in toluene furnished the corresponding symmetric (s-BF₂C) and unsymmetric difluoroboron-derivatized curcumins (us-BF₂C) in good (60 - 99%) and moderate yields (23 - 42%) within 6 - 12 h, respectively.

SUBMITTER: Liu K 

PROVIDER: S-EPMC3607379 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature