Ultrathin polymeric coatings based on hydrogen-bonded polyphenol for protection of pancreatic islet cells.

ABSTRACT: Though transplantation of pancreatic islet cells has emerged as a promising treatment for Type 1 diabetes its clinical application remains limited due to a number of limitations including both pathogenic innate and adaptive immune responses. We report here on a novel type of multifunctional cytoprotective material applied to coat living pancreatic islets. The coating utilizes hydrogen-bonded interactions of a natural polyphenol (tannic acid) with poly(N-vinylpyrrolidone) deposited on the islet surface via non-ionic layer-by-layer assembly. We demonstrate that the coating is conformal over the surface of mammalian islets including those derived from rat, non-human primate (NHP), and human. In contrast to unmodified controls, the coated islets maintain their viability and β-cell functionalit

SUBMITTER: Kozlovskaya V 

PROVIDER: S-EPMC3607452 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature