Epigenetics and chromatin dynamics: a review and a paradigm for functional disorders.

ABSTRACT:

Background

Motility and functional gastrointestinal disorders have high prevalence in the community, cause significant morbidity, and represent a major health care burden. Despite major advances in our understanding of the cellular and molecular basis of gastrointestinal neuromuscular functions, many of these diseases still defy mechanistic explanations. The biopsychosocial model underlying the current classification of functional gastrointestinal disorders recognizes and integrates the pathogenetic role of genetic, environmental, and psychosocial factors but has not been associated with specific molecular mechanisms.

Purpose

Here, we propose that this integrative function is encoded in the chromatin, composed of the DNA and associated histone and non-histone proteins and no

SUBMITTER: Ordog T 

PROVIDER: S-EPMC3607505 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature