One-carbon metabolism factors and leukocyte telomere length.

ABSTRACT:

Background

Dietary and genetic factors involved in the one-carbon metabolism pathway may affect telomere length through DNA methylation and synthesis, but this has not been comprehensively investigated in epidemiologic studies.

Objective

We cross-sectionally examined associations between dietary and genetic factors in the one-carbon metabolism pathway and relative peripheral blood leukocyte telomere length.

Design

A total of 1715 participants from the Nurses' Health Study (NHS) had measurements of relative telomere length and plasma concentrations of folate, vitamin B-6, vitamin B-12, cysteine, and homocysteine. Food-frequency questionnaire (FFQ) measurements were also used for the assessment of folate, choline, methionine, riboflavin, vitamin B-6, vitamin B-12, and a

SUBMITTER: Liu JJ 

PROVIDER: S-EPMC3607653 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature