Y chromosome microdeletions in infertile men: prevalence, phenotypes and screening markers for the Indian population.

ABSTRACT:

Purpose

Yq microdeletions are the leading genetic cause of male infertility and its detection is clinically relevant for appropriate genetic counseling. We aimed to determine the prevalence and type of Yq microdeletions, the associated seminal phenotypes and the STS markers that are relevant for its testing in Indian population.

Methods

Yq microdeletion analysis was carried out in 1,636 infertile cases in our centers. Additional data was collected from published studies in Indian population leading to a total of 3,647 cases.

Results

In our cohort, 3.4 % (56/1,636) of infertile men had Yq microdeletions. Combining the data from other published studies identified 215/3,647 (5.8 %) infertile individuals to harbor Yq microdeletions; with 6.4 % in azoopsermia, 5.8 % in oli

SUBMITTER: Sen S 

PROVIDER: S-EPMC3607676 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature