A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.

ABSTRACT:

Background

Venous Thrombosis (VT) is a common multifactorial disease with an estimated heritability between 35% and 60%. Known genetic polymorphisms identified so far only explain ~5% of the genetic variance of the disease. This study was aimed to investigate whether pair-wise interactions between common single nucleotide polymorphisms (SNPs) could exist and modulate the risk of VT.

Methods

A genome-wide SNP x SNP interaction analysis on VT risk was conducted in a French case-control study and the most significant findings were tested for replication in a second independent French case-control sample. The results obtained in the two studies totaling 1,953 cases and 2,338 healthy subjects were combined into a meta-analysis.

Results

The smallest observed p-value for int

SUBMITTER: Greliche N 

PROVIDER: S-EPMC3607886 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature